Synthesis and Modification of some Heterocyclic Compounds with Potential Biological Activity Coupled on Poly (Maleic Anhydride – Methyl Methacrylate)

This paper presents some results concerning the immobilization through chemical bonds of some biologically active compounds on the maleic anhydridemethyl methacrylate) copolymer. The high reactivity of the anhydride cycle of the polymer has allowed us to obtain conjugates in which the biologically active compounds of some heterocyclic compounds are immobilized on the polymeric support through amide bonds. The reaction products were characterized through elemental analysis, mass spectra, FTIR and HNMR spectroscopy. The antimicrobial activity of the modified copolymer was tested against various microorganisms (Staphylococcus aureus, Escherichia coli, pseudomonas aeroginosa, Klebsiella and fungal, Aspergillus niger, Aspergillus Flavus and Fusarium oxyspoium). In general, the copolymers showed good antimicrobial activity against the previously mentioned microorganism. [Journal of American Science 2010; 6(8):512-524]. (ISSN: 1545-1003). key words : Synthesis , Copolymer, Heterocyclic, Antibacterial activity.